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By the late 20th century, researchers were beginning to realize that studies on various diseases or treatments were sometimes not coming out as they expected; they realized that a clinical study consisting of mostly men, for example, provided information that often did not apply to women. As a matter of fact, the information was often shockingly different.
In the mid-20th century, Dr. Lawrence Craven, a physician in California, noted that children who were given aspirin after having their tonsils removed often had bleeding problems. He began to think that it was the aspirin product that prevented the blood from clotting, and it occurred to him that perhaps this would help with heart disease. After examining the medical records of 8,000 aspirin users, he found that none had had heart attacks, so he invited other physicians to examine the issue.
In 1983, Dr. Charles Hennekens of Harvard Medical School undertook a study of 22,000 healthy male doctors, all of whom were over the age of 40. The study showed a reduced rate of heart attack but a greater likelihood of bleeding in the brain. This information has led to the recommendation that people with bleeding problems should avoid aspirin, but that other people should take a low dose to maintain heart health.
Finally in 2005, a study of women was conducted. The results of this study showed that for women aspirin did not reduce the risk of a first heart attack but it brought down the risk of stroke by 17 percent. These results were counter to what was learned about men.
From studies such as these, scientists are now aware that gender is one more variable that needs to be carefully factored in when diagnostic methods and treatment remedies are being studied. . .
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